THURSDAY, MAY 20, 2010

8:30             Registration

9:00             Jacques Young, Paris, France :  Introduction

SESSION 1   Basic

Chairs : Najiba Lahlou, Alain Gougeon

9:10              Alain Gougeon, Lyon, France
                     Ovarian follicular developpment in primates : facts and hypotheses.

9:30              Marco Conti, Stanford, USA
                     Cyclic AMP and meiotic arrest in mammalian oocytes.

10:00             Martin M. Matzuk, Houston, USA
                      Oocyte-somatic cell communication and microRNA function in the ovary.
           
10:30            Jenny Visser, Rotterdam, Netherlands
                     AMH : marker and regulator of ovarian function.

11:00-11:30             Coffee break

SESSION 2   GnRH-Gonadotrophin-ovarian axis

Chairs : Anne Bachelot, Catherine Dodé

11:30            Jean Pierre Hardelin, Paris, France           
                     Genetic control of GnRH neurons ontogenesis.
                       
11:50            William H. Colledge, Cambridge, UK           
                     The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice.
           
12:20            Manuel Tena-Sempere, Cordoba, Spain
                     KiSS-1/kisspeptins and the metabolic control of reproduction : physiologic roles and physiopathological implications.

12:50-14:15            Lunch (free)
           
14:15            Jacques Young, Paris, France           
                     Congenital hypogonadotropic hypogonadism in women : the clinical spectrum and genetics.
           
14:35            Alessandro D. Genazzani, Modena, Italy           
                     Functionnal hypothalamic amenorrhea.

SESSION 3   From mice models to human diseases

Chairs : Nadine Binart, Yves Morel

15:00            Ilpo Huhtaniemi, London, UK
                     Ovarian consequences of gonadotropin and gonadotropin receptor genetic manipulations in mice.
           
15:30-16:10 Coffee break – Poster Session

16:10            Philippe Touraine, Paris, France
                     Genotype/phenotype relationship of gonadotropin receptor mutations in women.

16:35            Patrice Rodien, Angers, France           
                     Ovarian hyperstimulation syndrome due to mutations in the Follicle-Stimulating Hormone Receptor.

17:00            Philippe Chanson, Paris, France
                     Ovarian dysfunction due to Gas activation: the McCune Albright model

End of the day 17:25

FRIDAY, MAY 21, 2010
SESSION 4   Premature ovarian failure

Chairs : Philippe Touraine, Anne Guiochon-Mantel

9:00              Gerard Conway, London, UK
                     Premature ovarian failure and FMR1 gene mutations : an update.

9:25              Elfride De Baere, Ghent, Belgium
                     Role of FOXL2 impairment in syndromic and non-syndromic POF.

9:50              Anu Bashamboo, Paris, France
                     Mutations in NR5A1/SF1 and ovarian insufficiency.

10:15             Sophie Christin-Maitre, Paris, France
                      Genome-wide association scans and identification of news susceptibility loci for premature ovarian failure.

10:40-11:10            Coffee break – Poster session

SESSION 5   PCOS: pathophysiology and treatment

Chairs : Anne Caufriez, Michel Pugeat

11:10            Paolo Beck-Peccoz, Milan, Italy
                     PCOS : unresolved issues and new questions.
                       
11:30            Corinne Vigouroux, Paris, France
                     What have we learned form monogenic  forms of PCOS/HAIRAN associated with severe insulin resistance.

11:50            Stephen  Franks, London, UK
                     Follicle dynamics and anovulation in polycystic ovary syndrome.
                       
12:20            Didier Dewailly, Lille, France
                     Which morphological investigations and how to interpret them to make the diagnosis of PCOS.
           
12:40            Philippe Bouchard, Paris, France
                     PCOS and ovulation induction, an up to date of different medical approchaes.
                                   
13:10-14:10            Lunch (free)

SESSION 6   New therapeutic approaches in ovarian pathology

Chairs : René Frydman, Catherine Poirot

14:10            Nadine Binart, Paris, France
                     Immature cryopreserved ovary transplantation in mice : efficacy and epigenetic marks.

14:40            Jacques Donnez, Brussels, Belgium
                     Restoration of ovarian function by transplanted cryopreserved ovarian tissue in women.

15:10            Helen Picton, Leeds, UK
                     The in vitro growth and maturation of ovarian follicles-the facts and the future.
                       
15:40            Yves Le Bouc, Paris, France
                     Is medical assisted reproduction devoid of epigenetic risk ?

16:10            Philippe Bouchard, Paris, France : Conclusion

16:25             End of the symposium